Project Summary Dr. Bannuru’s long-term career goal is to combine expertise in clinical medicine, clinical research and mind- body medicine, in a way that allows him to identify key clinical opportunities, and to lead multi-disciplinary research to develop models that allow for a more flexible evidence-base for the practice of personalized medicine. Dr. Bannuru received postdoctoral fellowship (T32 & F32) to train in clinical research and gain an introduction to comparative effectiveness research. The overall objective of this K23 proposal is to provide Dr. Bannuru protected time to acquire advanced skills and experience in mind-body medicine research necessary to achieve his long-term goal. The proposed career development plan will enable Dr. Bannuru to achieve his immediate career goal of refining and consolidating his research skills in the development of predictive models and risk stratification models, extending methods he has employed on one level (study level) to another level (patient-level) data, learning other modeling techniques (such as individual patient data (IPD) analysis), and increasing his fund of knowledge regarding Complementary and Integrative Medicine (CIM) so that the mind- body therapy evidence-base developed is more applicable to individual patients. Career Development Activities: This proposed plan builds logically on his training as a physician, as well as his research education and prior work as part of his F32. With his mentors, Dr. Bannuru has crafted a comprehensive training plan consistent with his career goals. The plan will engage him in robust training activities including: 1) structured mentorship; 2) specific training in mind-body medicine research; 3) constructing and managing the database for IPD analysis; 4) advanced training in IPD network meta-analysis, predictive modeling and responsive sub- group analysis; 5) research project; 6) workshops and seminars; 7) scientific writing and grantsmanship; and 8) responsible conduct of research. Dr. Bannuru has assembled a team of mentors with complementary expertise in the key areas of mind-body medicine, osteoarthritis, IPD methodology, predictive analytics and statistics. In addition to providing scientific guidance, his mentors will also offer career advice and facilitate new research collaborations which will allow him to broaden his professional network. Environment: Dr. Bannuru will benefit from the wealth of resources available to young investigators at the Tufts Medical Center. His association with Tufts Center for Complementary and Integrative Medicine, Tufts Clinical and Translational Science Institute and Brown University Evidence Practice Center provides an ideal environment for interaction with well-known researchers in the field of mind-body medicine and comparative effectiveness research which, going forward will help him to enhance his expertise in state-of-the-art research methods, and develop into an independent investigator. Research: Osteoarthri...