Project Summary The overall goal of the proposal is to perform extensive preliminary work that would ultimately lead to interoperability and to automatic data exchange between the GO and Reactome resources. We do not expect to fully achieve interoperability with a supplement, but, rather, the supplement will support the work needed to identify all the issues that need to be addressed, and to test solutions for these issues. The work proposed in this supplement will enable us to develop a detailed plan which would be necessary for future grant applications. In addition, based on an initial analysis that GO and Reactome have already performed together, we also expect substantial short-term benefits from the supplement: it will allow us to achieve interoperability for nearly all metabolic pathways (though not signaling pathways). For the broader genomics community, this work will result in a more fully interoperable set of major genomics resources and a model for coordination among resources to identify and share definitive sources of reference information for improved curation efficiency with minimal redundancy. Our work will utilize BioPAX-formatted data, thereby also enhancing interoperability of GO with any resource that utilizes BioPAX (these resources are integrated in PathwayCommons). This interoperability will also eventually make curation more efficient, as information curated in one project will greatly accelerate curation in other projects.