Abstract The FASEB Science Research Conference on Lysophospholipid and Related Mediators: From Bench to Clinic will be held July 11 - July 16, 2021 at the Grand Hotel Malahide, Ireland. This conference will address current research and emerging concepts related primarily to the lysophospholipids sphingosine 1-phosphate (S1P) and lysophosphatidic acid (LPA) and their roles in health and disease. S1P and LPA are signaling lipids that activate 5 and 6 G protein-coupled receptors, respectively, and bind to intracellular target proteins to regulate cell biology. These biological interactions control vital functions in the cardiovascular system, the immune system, and the nervous system. These lipids are important in pulmonary fibrosis, atherosclerosis, cancer, autoimmunity, and other disease states. Both receptors and enzymes regulating lysophospholipid metabolism have been shown to function as potential therapeutic targets to diagnose, prevent or treat disease. The conference will emphasize the translation of this work into clinical practice and highlight the research advances being made at a rapid pace by many new investigators in this field. The meeting provides a unique and invaluable forum for scientists from diverse disciplines to meet and discuss their latest research findings. The conference aims are to 1) provide intellectual exchange between scientists and trainees from multiple disciplines engaged in lysophospholipid research; 2) encourage and facilitate active discussion between early career and new investigators and established scientists via interactive career workshops and multiple opportunities for networking/collaboration; and 3) provide a platform to promote the participation of women and underrepresented minorities. The conference will allow diverse early career and established investigators to communicate late-breaking research results and promote future interactions aligned with developing therapies for diseases in which lysophospholipids play a predominant role. The conference site in Ireland will facilitate maximum participation of European scientists, scientists from other countries abroad, and US counterparts to promote productive interactions focusing on the translational implications of lysophospholipids.