We have gained valuable knowledge and lessons from our past experience with contacting patients to participate in research studies and propose to address them in the iAGREE study. These lessons include the following: Patients are unaware that their “de-identified” data can be shared for research purposes without consent, and most patients do not know their data are being shared for research and who may have accessed their data for what type of research. Even when identifiable data that involve an approval process are involved, e.g., genomes, the granting of consent waivers is highly variable among institutions. Patients are satisfied when given the opportunity to choose when and with whom to share which portions of their data, and their participation levels in research did not have an adverse effect with this opportunity. Through iAGREE, we will meet with stakeholders to define their needs, develop data sharing policies, and gather their assessment of the fit of the developed platform to their expressed needs. The developed platform will be an electronic consenting platform that authenticates patients and records their consent, all queries that use their consented data, and meta-data on query results that have been shared with data requestors. We will dis-intermediate the process of checking which data can be made available to researchers by binding researcher requests to data that use a common data model and redact using the patient consents. Our platform will increase transparency in the use of patients’ data. For example, any institutional representative can check that patients’ consents were followed in a data request, and patients can view which studies used their data. Furthermore, patients would only need to make choices once for all institutions where their data are stored, or choices may be institution-specific. Patients will also receive a notification before their data are used to respond to a data request, and they will have the opportunity to change their data sharing preferences based on the study information or leave permissions as is. We will deploy this platform at the seven institutions participating in this project. These collaborating sites consist of both private and state-owned institutions, so this project will uncover policies that meet local as well as state regulations.