PROJECT SUMMARY The 2022 Gordon Research Conference on Lymphatics will bring together leading international scientists and clinicians working across all aspects of lymphatic vessel biology to discuss the latest advances in this exciting and dynamic field. The meeting will feature cutting edge science in developmental biology, genetics, physiology, aging, oncology, immunology, metabolism, mechanobiology, neurodegenerative diseases, systems biology, mathematical modeling and human disease. Fueled by advances in our understanding of the biology and regulation of the lymphatic vasculature and its active roles in human health and disease, the lymphatic vasculature will continue to be a focus for novel discovery and therapeutic intervention. The primary goal for this meeting is to serve as a forum to communicate the latest research advances in lymphatic biology as well as provide the opportunity to build collaborative partnerships between scientists, clinicians, industry and philanthropy. Ample opportunities for the presentation of research by early career investigators and underrepresented minorities will be provided. It is expected that all presenters will discuss unpublished data and be present at all meals throughout the meeting to help catalyze scientific exchange and collaboration. Building on the success of previous years, the 2022 Gordon Research Conference on Lymphatics will be preceded by a Gordon Research Seminar on Lymphatics organized by Drs. Kerstin Wilhelm and Nils Hansmeier. The Gordon Research Seminar is organized by postdoctoral fellows to provide additional opportunities for junior investigators to present their work and form collaborations with their peers. The 2022 Gordon Research Conference on Lymphatics will also host a “Power Hour” to discuss different biases, with a focus on racial biases and burdens placed on URMs in science in order to start to build a more diverse, equitable and inclusive research community. We are also in discussions to hold a patient session to allow researchers to learn from patients suffering from lymphatic diseases. The sponsoring organization for this conference is Gordon Research Conferences, an organization dedicated to advancing the frontiers of scientific research. In accordance with its mission, this conference will place an emphasis on the presentation of unpublished data, high quality science and rich discussions. Participation of investigators from different disciplines will foster growth of the field and advance knowledge not only of lymphatic vascular biology and pathology, but also stimulate interdisciplinary research in many other fields such as cardiovascular disease, cancer, immunology, metabolism and neurobiology, among others. The participation of junior investigators through the Gordon Research Seminar will provide opportunities for scientific and professional mentorship with more senior investigators as we look to grow the field in the future.