ABSTRACT The Robert H. Lurie Comprehensive Cancer Center (LCC) of Northwestern University has strongly endorsed and agreed to share its Pathology Core Facility (LCC PCF) with NU-CHERS investigators through the establishment of the NU-CHERS Gynecologic Biospecimen Pathology Shared Resource Core (GBPC) in furtherance of the overarching goal of the NU-CHERS P20 application to support innovative translational research to elucidate and eliminate a broad spectrum of gynecologic cancer disparities. The GBPC will maintain the NU-CHERS Community Gynecologic Biobanking Collection (CGBC), enhancing the LCC PCF biospecimen collection by procuring a robust and diverse collection of gynecologic cancer specimens from Chicago’s largest public hospital, the John H. Stroger Jr, Hospital of Cook County (SHCC). The Director of the LCC-PCF, Jian- Jun Wei, MD is Co-Director of the NU-CHERS GBPC, underscoring the commitment of the LCC PCF to the infrastructure development and translational research proposed in the NU-CHERS application to reduce gynecologic cancer disparities. Working in tandem with Dr. Wei is GBPC Co-Director, Thomas Lad, MD who is Principal Investigator of the SHCC’s Minority Underserved NCI Community Oncology Research Program. The GBPC has the following Specific Aims. Aim 1: Engage NU-CHERS affiliated site John H. Stroger Jr, Hospital of Cook County in developing the Community Gynecologic Biobanking Collection (CGBC) a comprehensive biorepository of well-defined gynecologic tumor types, paired with clinical and pathologic data, from racial/ethnic minority and reference populations. Aim 2: Provide research histology and pathology services to NU-CHERS investigations of molecular-based gynecologic cancer disparities in minority populations. Aim 3: Support clinical trials led by NU-CHERS investigators and aimed at minimizing molecular-based gynecologic cancer disparities in minority populations that require the analysis of correlative components. Aim 4: Expand community-engaged research capacity among NU-CHERS research project and DRP investigators through community-tailored, reciprocal education and training in the procurement of racial/ethnic minority biospecimen. Aim 5: Participate in ongoing evaluation and transition planning to develop GBPC into a full P50 SPORE shared resource core.