The goals of the Nebraska Center for Molecular Target Discovery and Development (CMTDD) are to (1) provide the means necessary to define, validate, and develop potential therapies against disease targets, and (2) facilitate the professional and scientific development of early-stage investigators. Consistent with the scope of the CMTDD mission, the aim of this supplemental request is to purchase a MERSCOPE (Vizgen, Inc.) and provide spatial transcriptomics capability to early-stage investigators of the Nebraska Center for Molecular Target Discovery and Development (CMTDD) and other COBREs in the University system. MERSCOPE will be a cornerstone of the CMTDD omics resource, which will lower the cost barrier for investigators whose research papers and grant applications would benefit from the generation and analysis of complex data sets.