PROJECT SUMMARY The focus of this project is to identify “Mental Health” issues in mothers of children with CL/P in the presence of incidental findings from whole genome sequencing (WGS) of cleft triads supported by R01 DE028300. WGS provides an opportunity for the identification of “incidental findings” that indicate an increased risk for traits like sickle cell anemia and other single gene disorders that may have immediate medical implications for those in the study or their family members. We plan to determine the mental health experiences and quality of life in mother and child dyads with cleft abnormalities and to evaluate levels of behavioral difficulty in children with an orofacial cleft and relationship with quality of life and the mental health difficulty in their mothers in the presence of incidental findings. This is both a bioethics research study and capacity building opportunity in bioethics. This study will be led by Dr. Butali at the University of Iowa in collaboration with Dr. Yewande Oshodi and Dr. Adeyemo at the University of Lagos.