PROJECT SUMMARY This application is a request for bridge funding for the “Specific Pathogen Free Baboon Research Resource” (SPFBRR) P40 OD024628. The SPFBRR was founded with NIH support at the University of Oklahoma Health Sciences Center (OUHSC) in 2002 and was relocated to the Keeling Center in 2017. The SPFBRR has received continuous NIH support since it was founded. The SPFBRR is the only national research resource of adventitious virus free olive baboons (Papio anubis) that are available to NIH grantees; intramural research programs of federal agencies, including the FDA, NSF and NIH; and other sponsors of biomedical research (private foundations, pharmaceutical companies, and contract research organizations). Absolutely unique in the entire world, the baboons in the SPFBRR have an extensive bioexclusion list of 18 pathogens normally found in other wild and captive nonhuman primate colonies. The SPFBRR has integrated multiple disciplines into a program designed to meet the needs of investigators who utilize its resources. During the proposed period of support, the SPFBRR will continue to improve the resources it provides to users and will continue to add new information about the biology and research value of virus free baboons to its website. Baboons continue to be important animal model for genetically engineered pig xenotransplantation, are the only NHP model of respiratory syncytial virus and whooping cough, and they remain a very important model of bacterial sepsis. Additionally, baboons are excellent models of human COVID associated pneumonia, and they were instrumental in the development of approved vaccines for SARS CoV-2. Over the next year the SPFBRR will focus on maintaining the SPF18 baboon breeding colony to meet current and future biomedical research needs. The overall goal of the SPFBRR is to provide a national research resource of virus free olive baboons; provide baboon derived biological materials; provide education and training opportunities to scientist, colony managers, and animal caregivers who want to work with baboons; and to provide investigators with facilities and expertise to conduct studies using virus free baboons.