Project Summary/Abstract Nonalcoholic fatty liver disease (NAFLD) affects one in three adults and one in five children in North America and is a growing public health issue in the United States and many parts of the world. NAFLD, and especially nonalcoholic steatohepatitis (NASH), may lead to cirrhosis requiring liver transplant, and liver cancer, as well as liver-, cardiovascular-, and cancer-related morbidity and mortality, resulting in increased health burdens and associated costs. The Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN) has been sponsored by the National Institutes of Health (NIH) since 2002 and has provided important information regarding the natural history and treatment of NAFLD and NASH in adults and children, and has set the stage for translational research focused on the pathogenesis, diagnosis, treatment, and clinical management of these patients. This supplement application is in response to the Administrative Supplements to Existing NIH Grants and Cooperative Agreements (PA-20-272) as part of our parent award Limited Competition for the Continuation of the Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN) Data Coordinating Center (DCC). The DCC aims for the continuation in response to the PA are: 1) To initiate and complete the Vitamin E dosing study (VEDS) treatment trial and 2) To provide the DCC functions necessary to complete VEDS including: research leadership, financial management and disbursement of per capita payments to the VEDS clinical centers, expertise in biostatistical analysis, data management, multicenter coordination, quality control methods, safety oversight, project support, communication, and organization. The DCC has worked productively with the clinical centers in the past and is eager to continue its collaboration with the clinical centers as well as with NIDDK program staff, to complete these important research objectives. The NASH CRN is poised to continue its major impact on the field and directly advance the mission of the National Institutes of Health to improve the health of the public.