PROJECT SUMMARY Under the proposed pilot, the respective biorepositories of the Children’s Hospital of Philadelphia and the Crnic Institute Human Trisome Project Biobank will partner with the INCLUDE Data Hub to define and implement the required workflows and tools to support biosample-based data/meta data integration. Such efforts will empower portal users to engage cohort creation and biosample use frameworks via the INCLUDE Data Hub and their downstream interactions with repositories as a combination of centralized and federated resources.