Cognitive, motor, and mental health consequences of central nervous system are debilitating conditions that impair the quality of life and community reintegration of many Veterans. These outcomes occur as the result of damage to neural networks, and restoration of function from such damage is the ultimate goal of neurorehabilitation. The brain has a remarkable ability to grow new neuronal connections and recover from injury if it is exposed to appropriate experiences. The long-range strategic plan of the Brain Rehabilitation Research Center (BRRC) is to harness mechanisms of experience-dependent neuroplasticity and neural network reorganization to develop, test, and implement rehabilitative treatments for cognitive, motor, and emotional-neuropsychiatric disability in Veteran survivors of traumatic brain injury (TBI), spinal cord injury (SCI) and stroke. Treatment efficacy requires proper engagement of restorative and compensatory brain mechanisms. For example, the BRRC seeks to develop behavioral interventions that specifically engage impaired neural networks, in some cases with augmentation from non-invasive neuromodulatory adjuvants. Treatment efficacy also requires minimizing the presence of factors that interfere with neuroplastic changes. For example, the BRRC seeks to counteract injury-related problems such as neuroinflammatory and neurotoxic effects with pharmacological interventions, as well as to mitigate the compounding effects of advancing age and/or poor systemic health. The BRRC’s research portfolio consists of rigorous preclinical (animal) and clinical (human) investigations that drive the development of treatments that not only potentiate positive neuroplastic change through rehabilitation, but also mitigate factors that deter the brain’s ability to repair and recover after injury. Further, the BRRC aims to increase the accessibility of treatments, including through teletherapy and at-home interventions. The BRRC is comprised of a multi-disciplinary team of scientists in a highly collaborative environment that is fertile for translation of basic science discoveries to the real-life rehabilitation of Veterans with injury-related disabilities. The Center organization reflects three primary research initiatives: Cognition/Emotion, Motor Function, and Rehabilitation Neuroscience, supported by an Administrative Core, a Neuroimaging and Biomarker Measurement Core, and a Human Motor Performance Measurement Core. The Center’s research has a mechanistic focus, is increasingly trans-disciplinary and features projects that cut across initiatives and cores. Its Neuroimaging and Biomarker core broadly supports current investigations by providing infrastructure for acquisition and analysis of neuroimaging and biomarkers of injury, disability and rehabilitation-related neuroplastic change. The BRRC plays an important role in national brain injury consortium projects, furthering both clinical and basic science. The BRRC, and the Veterans it serves...