Project summary/abstract Supplemental funding is requested for the purchase of an automated flash chromatography system. This automated system will greatly facilitate and accelerate the chemical synthesis of model compounds to develop fundamental principles of proton-coupled electron transfer (PCET) and the recently discovered proton-coupled energy transfer (PCEnT) process (reported summer 2022). The synthesis of new pure compounds for study is often the slow step in this research. The requested system is comprised of high-pressure pumps, pre-packed columns of various sizes and stationary phases, and a photodiode array detector for fractionation. This system fully automates and improves the traditional time-intensive and labor-intensive column chromatography for separation of the products of chemical reactions. This system will enable the rapid and efficient purification of both the desired compounds for study and the synthetic intermediates along the pathway to the final products. Therefore, the automated flash chromatography system will accelerate the planned research and allow extensions to wider groups of compounds and to new model systems. More ready availability of compounds to study are particularly important in the growing collaborative efforts, in which our laboratory has been the generator and synthesizer of new molecules. In particular, the team’s discovery of PCEnT brings new challenges to synthesize molecules that will proceed by this pathway or by PCET.