Abstract: This proposal aims to secure funding for acquiring a new generation EchoMRI whole body composition analyzer to address the urgent need for reliable and advanced research capabilities that are critical to ensure uninterrupted progress and advance of federally funded projects at OHSU. The new EchoMRI analyzer is capable of accurate measurements of whole-body composition in small live animals, which is crucial for investigating metabolic disorders, monitoring chronic disease progression and understanding disease mechanisms over time, especially in young animals and during early development. The instrument currently available for OHSU researchers is 16 years old, obsolete in both hardware and software, plagued by frequent and unpredictable malfunctions, dwindling manufacturer support, and incompatible to upgrading. Its increasingly frequent breakdowns have caused significant disruptions, delays and data loss in NIH-funded studies. The requested new analyzer, with the latest versions of hardware and software and enhanced capabilities,will not only solve the problemof unpredictableunavailability, but will also offer expanded test modalities, new measurement capabilities, improved measurement accuracy and enhanced data safety. It will be procured from the same vendor of the instrument currently used at OHSU, EchoMRI LLC, which can ensure a seamless transition. The new analyzer will cost $136,650 and will be managed by the OHSU University Shared Resources (USR) program, providing access to at least nine NIH-funded research groups and other OHSU affiliated institutions. With an optimized operation and management team in place, acquisition of the new EchoMRI analyzer will empower researchers, facilitate breakthrough discoveries, and contribute to solving critical health issues through investigations on metabolic and endocrinological pathogenesis and pathophysiologic mechanisms of a broad range of chronic diseases, of which comprehensive body composition analysis is often an indispensable and critical part. This proposed investment holds great potential for transformative impacts on research outcomes and the advancement of excellence in biomedical research.