The goal of this post-baccalaureate research supplement is to enhance the impact of the parent R01 by supporting a highly motivated recent, University of Vermont Biological Sciences graduate for a 2-year research experience. The proposed supplement experience is designed to provide the candidate with the resources, mentorship, and skills required to complete an independent research project, which is a logical extension of the aims of the parent R01. The proposed project, described in the Research Plan, has been designed to give the candidate mentored, first-hand experience in four phases of scientific research: 1) Rationale and experimental design; 2) reagent production and experimentation; 3) data analysis and interpretation, and; 4) communication of results. In addition, the candidate will have the opportunity to gain expertise in the pathogenic mechanisms of inherited cardiomyopathies, a critical area of human health, prior to attending medical school in the Fall of 2025.