Project Summary/Abstract Acute pancreatitis is a common inflammatory disorder with short- and long-term clinical sequelae. The development of diabetes mellitus following an episode of acute pancreatitis (termed AP-related DM) is now recognized in approximately 25% of patients; however, its epidemiology and pathophysiology remain poorly characterized. These knowledge gaps limit our ability to identify which patients are most likely to develop this metabolic complication and design targeted prevention and treatment strategies. Therefore, we have developed a prospective, longitudinal, observational cohort study in AP, along with a series of hypothesis- driven investigations in AP-related DM. We propose The Ohio State University Clinical Center (OSU-CC), an innovative, strategically aligned, multi-disciplinary team of nationally-recognized experts to address knowledge gaps in AP-related DM and work collaboratively with other selected Clinical Centers within the framework of the NIDDK to form the Type 1 Diabetes in Acute Pancreatitis Consortium (T1DAPC).