ABSTRACT – CENTER OVERVIEW The main goal of the University of Michigan O'Brien Kidney Translational Resource Center (MKTC) is to provide an effective translational research pipeline to develop novel, mechanistic treatment strategies for patients with kidney diseases. The center will support all basic and patient-oriented kidney research investigators using a 3-pronged approach: Enable investigators to investigate the molecular causes and endpoints of acute and chronic kidney diseases; Dissemination and support of the most modern and powerful systems biological approaches for all investigators to help them effectively identify novel and robust biomarkers, endpoints and targets for diagnosis and treatment of AKI and CKD; Expert analysis and integration of cohort and systems data for our research base investigators through the use of sophisticated bioinformatics and database integration that promote identification of specific pathways and targets for treatments for individuals or groups of subjects with AKI and CKD. The Center's aims are to: 1) Introduce, stimulate and apply state-of-the-art systems biological approaches to kidney disease research investigators through the use of sophisticated but user-friendly genetic, transcriptomic, proteomic, metabolomic and lipidomic approaches through the Applied Systems Biology Core; 2) Enhance the understanding of complex kidney diseases and the multi-scalar data sets that accompany systems biological approaches to their functional implications regarding kidney disease development, diagnosis, progression and therapeutic potential through the Data Analytic Services Core (DASC); 3) Serve as national resource and expand worldwide outreach efforts via Nephroseq, Nephrocell and tranSMART; 4) Use the Student Programs and robust enrichment programs to entice trainees and faculty into kidney research, improve diversity, equity and inclusion and support researchers in their ongoing kidney research. 5) Share best practices and resources with the other National Resource Centers under the U54 consortium and work with Data Coordinating Center to enable widespread dissemination.