PROJECT SUMMARY / ABSTRACT This project is intended to support the applicant as a clinician-scientist in leukemia at Washington University School of Medicine / Siteman Cancer Center supporting NCI-funded clinical research. As Medical Director for Clinical Research, the applicant will support the implementation of clinical research at the institution by 1) improving operational efficiency, 2) expanding program capabilities, and 3) ensuring protocol compliance to achieve the highest quality conduct of clinical trials that can improve the lives of patients with cancer. The applicant will also provide scientific leadership to NCI-funded research as co-chair of the Leukemia Committee of the Alliance for Clinical Trials in Oncology and the Older AML Clinical Basket for myeloMATCH, the NCI Precision Medicine Initiative in myeloid malignancies. The Leukemia Committee of the Alliance will continue to conduct practice-changing treatment trials and further our understanding of the biological basis of leukemia and its treatment. In addition, the Committee will address health disparities in leukemia by increasing the accrual of underrepresented minorities and assessing the impact of social determinants of health. In older adults with AML, myeloMATCH will test the combination of targeted therapies with hypomethylating agents and venetoclax to improve remission rates and validate the prognostic significance of flow cytometry- based measurable residual disease. A companion geriatric assessment will be implemented across treatment studies to validate measures that predict treatment tolerance and benefit.