Abstract Summary Vagus Nerve Somatotopy using the COSMIIC System In this Supplement, we will use the COSMIIC Platform System components to assess the impact of chronic fibrous encapsulation on evoked recording from the cervical vagus nerve immediately post-implant and chronically over time. Recent studies have provided basic proof of concept that smaller, multi-contact electrodes may stimulate specific portions of the cervical vagus to selectively activate intended therapeutic pathways while minimizing co-activation of off-target pathways. These studies were performed acutely under anesthesia. In this supplement, we intend to leverage the HORNET system for chronic stimulation and recording to develop pilot data to address these gaps. The aims of this supplement are: 1) assess the impact of chronic fibrous encapsulation on evoked emg, eng, and physiological responses over time with continuous stimulation started immediately post-implant, and 2) assess the impact of chronic continuous stimulation started 1-month post-implant on evoked emg, eng, and physiological responses over time.