Project Summary The Data Science Shared Resource (DSSR) of the H2CAREE initiative aims to provide comprehensive data support, ensure data integrity, and facilitate FAIR (findable, accessible, interoperable, and reusable) data curation. DSSR is co-led by a team of experts from Johns Hopkins University Sidney Kimmel Comprehensive Cancer Center, and Howard University, with diverse backgrounds and complementary expertise. The DSSR will implement advanced database technologies, optimize data access, and establish an analytical framework for scientific rigor and reproducibility. The DSSR plans to develop advanced curation tools, incorporate artificial intelligence, and create analytic tools to manage data. The shared resource will also focus on integrating health equity and disparity attributes into the existing data model and developing an analytics infrastructure to improve health equity. The DSSR is committed to continuous advancement, promoting collaborative code sharing, and developing models that employ statistical methods, artificial intelligence, and machine learning to deepen understanding and improve cancer health equity.