Project summary. This proposal is for the acquisition of an Agilent Ultivo Triple Quadrupole LC/MS System for high-throughput multiplex enantiomeric screening, aimed at developing new biocatalysts for enantioselective non-natural transformations. The application entails justifications for this purchase and delineates how this new instrument would facilitate our R35 research, improve the productivity of my laboratory, and expand the new research horizons of our work. It also provides justification for the need of this instrument as well as justification for the price of the instrument being purchased.