Mechanistic insight into the regulation of the apical bile acid transporter (ASBT) using chemical biology approaches

NIH RePORTER · NIH · P20 · $254,100 · view on reporter.nih.gov ↗

Abstract

The proposed research is relevant to public health due to the essential role of bile acids in the regulation of lipid and glucose metabolism. Identification of mechanisms that modulate the stability of the human apical bile acid transporter may facilitate the development of innovative therapeutic strategies to restore bile acid flux and signaling in humans.

Key facts

NIH application ID: 11063575
Project number: 5P20GM130456-05
Recipient: UNIVERSITY OF KENTUCKY
Principal Investigator: Lindsay Christine Czuba
Activity code: P20
Funding institute: NIH
Fiscal year: 2024
Award amount: $254,100
Award type: 5
Project period: 2024-02-01 → 2025-07-31