This Phase I SBIR contract is in support of Development of novel In-vitro and In-vivo Models to support NeuroHIV Research. hiPSC-NeuroHIV assay, an in vitro model system that mimics certain cellular components of the human brain using cells derived from human induced pluripotent stem cells (hiPSCneurons/ microglia/astrocytes). The hiPSC-NeuroHIV assay system will enable HIV-therapeutics and cART mixtures to be tested for both NeuroHIV effects (neurotoxicity), and for efficacy at blocking HIV replication. has context menu