Project Summary / Abstract Viral hemorrhagic fevers, of which Ebola virus (EBOV) and Lassa virus (LASV) are prototypical examples, are a major source of human suffering. Recent outbreaks have raised concerns about the possibility of a global outbreak. The ultimate goal of the Consortium for Viral Systems Biology (CViSB) is to define networks of host and viral factors that drive clinical outcomes in Ebola virus disease (EVD) and Lassa fever (LF). The responsibilities and contributions of the Technology Core fall into three main categories: data generation, technology development and standardization, and evaluation and incorporation of emerging technologies. Although these categories are distinct, they are tightly integrated. The Core’s role as data generation hub for CViSB also mandates that we continually work to develop and improve our methods and to rapidly incorporate novel technological advances to ensure that we remain a state-of-the-art, productive member of the Center. The Technology Core’s Aims are focused on the development, adaptation and standardization of innovative experimental approaches in four main areas: (1) deep characterization of the adaptive immune response to infection, (2) functional profiling of antiviral serum activity, (3) isolation and characterization of protective monoclonal antibodies and (4) cost-efficient viral genome sequencing. In addition to supporting the Center’s Projects and contributing to the overall success of CViSB, the Technology Core will translate its technical and methodological advances into standardized, reproducible protocols that will benefit other Centers and the broader infectious disease community.