Non-technical Abstract Molecules can arrange to form larger structures, a process that is key to both complex living tissues and new, advanced materials. For example, scientists have long studied how specific sequences of amino acids fold to create proteins that act as tiny machines. Similarly, surfactants (e.g., the molecules in soap) can assemble into spheres, layers, and tubes. In both cases, the assembled structure is important for their practical use. For example, long, tube-shaped surfactant structures help to thicken shampoos while also cleaning hair. However, the ability to form this tube-like structure is usually related to shape of the surfactant molecule itself. This project seeks to learn from the ways in which long, charged molecules with protein-like sequences attract oppositely-charged surfactants, and form materials with desired structures. This effort uses both experiments and computation and will benefit society and the U.S. by establishing a versatile class of biology-inspired materials for use across chemical, agricultural, and industrial applications. The research will also involve the interdisciplinary training of researchers with broad expertise in chemistry, engineering, and physics, via both student mentorship and engagement with K-12 students. Technical Abstract This project will establish how sequence-controlled polymers can be used for the rational design of surfactant-containing materials. This effort will leverage sequence-defined polype