Select Agent: Determination That Vaccine Strain, TC-83(A3G) of Venezuelan Equine Encephalitis Virus (VEEV) Is a Regulated Strain of VEEV
public-health · Centers for Disease Control and Prevention · Rule · Published 2022-09-01 · Effective 2022-09-01 · 87 FR 53679
Document
Document number
2022-18973
Federal Register citation
87 FR 53679
CFR reference
42 CFR 73
Type
Rule
Action
Regulatory determination.
Category
public-health
Sub-agency
Centers for Disease Control and Prevention
Publication date
2022-09-01
Effective date
2022-09-01
Abstract
The Centers for Disease Control and Prevention (CDC), located within the Department of Health and Human Services (HHS), has determined that a modification to the attenuated, excluded strain Venezuelan Equine Encephalitis Virus (VEEV) TC-83 has been shown to increase its virulence. The modified VEEV strain TC-83(A3G) demonstrated increased pathogenicity and lethality. Therefore, the modified VEEV strain TC-83(A3G) is not an excluded strain but is a select agent and is subject to regulation.