The contact's father owned a 2021 Ford F-150. The contact stated that while his father was driving at 75-80 MPH on self-driving mode, the electronic steering wheel inadvertently locked, causing him to lose control of the vehicle and the vehicle crashed into an exit sign on the interstate. The air bags deployed. Then, the vehicle accelerated uncontrollably 260 yards and crashed into a tree where the vehicle came to a stop. A police report was filed. The contact stated his father sustained injuries and was transported out of the vehicle to the hospital by emergency units. The contact stated his father deceased 4 hours later. The vehicle was towed to a tow lot, where it was totaled. The manufacturer was made aware of the failure. The approximate failure mileage was 2,000.