While driving on the highway, acceleration shuts down and I lose the ability to control speed. I had to coast to the side of the road even though the engine was still running and I was rear-ended. After I shut off the vehicle, it turned on and returned to normal operation. This has happened multiple times. The throttle body was replaced in 2021 at 117,444 miles and is having this issue again now. I have a fleet of Transit vehicles and this has happened on 4 transits from 2015-2018 a total of 6 times now. This is an ongoing issue that Ford needs to address.