The contact owns a 2002 Ford E-150. The contact stated while driving at approximately 75 MPH, he smelled a burning odor in the passenger cabin. The contact stated that he turned the A/C on to help clear the cabin. The contact stated that he noticed smoke was being emitted from the driver's side rear tire and wheel well. The contact stated that the tire separated from the rim and the vehicle dropped to the road. The contact stated he had not noticed any warning lights. The contact stated that he managed to pull over and saw smoke emitted from the rotor and brake pads. The contact stated that the rim was almost destroyed. The contact observed that there was fluid leaking from the rotor and brake pads and had started to burst into flames. The contact stated that he was able to smother the flames with a blanket. The contact stated that he had the vehicle towed to an independent mechanic. The vehicle was not diagnosed and was not repaired. The manufacturer was not informed of the failure. The failure mileage was approximately 228,000.