On highway for 2 hours, pulling 5th wheel trailer. Diesel Particulate Filter Cleaning alert went on. Immediately truck lost power, a few other alerts flashed on the screen that couldn't read in time then alert that truck was being put in Neutral which it did. Smoke coming out of engine compartment. Barely coasted to stop on side of freeway. Quickly turned from white smoke to brown. Barely enough time to get me, wife and dog out of the cab before flames coming out of engine. Engine and cab completely burned out.