On September 16, 2025, while driving my 2023 Ford F-250 Super Duty at approximately 65 mph with cruise control engaged, I pressed the brake pedal to disengage cruise. The cruise control did not disengage. I pressed the brake pedal harder, but the truck did not slow down and maintained speed. There was no ABS activation sound or sensation, and no skid marks were left on the roadway. I struck the rear of a tractor trailer because the vehicle failed to slow down or cancel cruise control. In addition, the airbags did not deploy during the collision. This appears to be a failure of the brake pedal input/cruise disengagement system, braking system, and potentially the airbag system. This is a severe safety defect that could result in serious injury or death.