While traveling on I-26 east near North Carolina MM 51 in the left lane, the vehicle suddenly pulled uncontrollably to the left resulting in a sideswipe of the guardrail. The vehicle then swerved to the right stopping near the center of the interstate. My wife was able to move the vehicle to the right shoulder under its own power. The right front tire/wheel was laying almost flat attached to the vehicle only by the brake line. The entire wheel assembly was detached from the steering/suspension system. The vehicle was towed to a local collision center and inspected by my insurance adjuster. The vehicle was determined a total loss. There were no injuries or other vehicles involved. The NC Highway Patrol responded but did not complete an accident report.