2005 LEXUS RX330 WOULD NOT STOP NOR BRAKE AS HEADED DOWNHILL IN SLIGHTLY SNOWY WEATHER AT ABOUT 25MPH. AS ROAD CURVED, I COULD NOT SLOW VEHICLE AND THUS STARTED TO LOSE STEERING CONTROL. I ATTEMPTED TO ACCELERATE THINKING IT WA A FORWARD SLIDE BUT THAT DIDN'T CHANGE THINGS AND VEHICLE CONTINUED TO ACCELERATE. SO I HIT THE BREAKS HARD-- NO RESULT, NO ADDITIONAL CONTROL. VEHICLE CONTINUED FOR ABOUT A BLOCK, HIT CURB, THEN TREE. TOTALED VEHICLE AND INJURY TO MYSELF. ASSUMED AT THE TIME THE SPEED WAS LOWER BUT AFTER SEEING DAMAGE LATER AND GETTING PHYSICAL THERAPY, IT CLEARLY HAD ACCELERATED BEFORE HITTING THE CURB-- WHICH DID SLOW IT DOWN BEFORE HITTING THE TREE. THREE OF FOUR TIRES BLEW OUT WITH HOLES ON THE SIDES FROM FORCE OF IMPACT WITH CURB. *TR